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Conjunctival transcriptomics in ocular mucous membrane pemphigoid.
Panthagani J, Suleiman K, Vincent RC, Ong HS, Wallace GR, Rauz S. Panthagani J, et al. Ocul Surf. 2023 Oct;30:142-149. doi: 10.1016/j.jtos.2023.09.005. Epub 2023 Sep 9. Ocul Surf. 2023. PMID: 37690517 Free article.
The top 4 upregulated DEGs represented fibrosis (COL3A1, COL1A1, FN1 and THBS1) while the key under-expressed genes (SCIN, HMGS2, XCL1/2) were indicative of ocular surface failure (goblet cell loss, keratinization, vulnerability to secondary infections). ...
The top 4 upregulated DEGs represented fibrosis (COL3A1, COL1A1, FN1 and THBS1) while the key under-expressed genes (SCIN, HMGS2, XCL1 …
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.
Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, Malefyt Rde W, Nitta T, Takahama Y. Lei Y, et al. J Exp Med. 2011 Feb 14;208(2):383-94. doi: 10.1084/jem.20102327. Epub 2011 Feb 7. J Exp Med. 2011. PMID: 21300913 Free PMC article.
We show that the chemokine receptor XCR1 is expressed by tDCs, whereas medullary thymic epithelial cells (mTECs) express the ligand XCL1. XCL1-deficient mice are defective in the medullary accumulation of tDCs and the thymic generation of naturally occurring regulat …
We show that the chemokine receptor XCR1 is expressed by tDCs, whereas medullary thymic epithelial cells (mTECs) express the ligand XCL1 …
Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease.
Kim MC, De U, Borcherding N, Wang L, Paek J, Bhattacharyya I, Yu Q, Kolb R, Drashansky T, Thatayatikom A, Zhang W, Cha S. Kim MC, et al. Commun Biol. 2024 Apr 19;7(1):481. doi: 10.1038/s42003-024-06124-6. Commun Biol. 2024. PMID: 38641668 Free PMC article.
Here we show that single-cell RNA sequencing identifies the subsets of IFN gene-enriched monocytes, CD4(+) T effector memory, and XCL1(+) NK cells as potential key players in childhood Sjogren's disease, and especially in those with recurrent parotitis, which is the chief …
Here we show that single-cell RNA sequencing identifies the subsets of IFN gene-enriched monocytes, CD4(+) T effector memory, and XCL1 …
Dynamic expression of chemokines and the infiltration of inflammatory cells in the HSV-infected cornea and its associated tissues.
Araki-Sasaki K, Tanaka T, Ebisuno Y, Kanda H, Umemoto E, Hayashi K, Miyasaka M. Araki-Sasaki K, et al. Ocul Immunol Inflamm. 2006 Oct;14(5):257-66. doi: 10.1080/09273940600943581. Ocul Immunol Inflamm. 2006. PMID: 17056459
Gene expressions of chemokines those work on T cells and B cells, such as CCL19, CCL21, CXCL9, CXCL13, CXCL10, XCL1, and CXCL16, were up-regulated and peaked at 3 days P.I. in the cornea and in the TG. ...
Gene expressions of chemokines those work on T cells and B cells, such as CCL19, CCL21, CXCL9, CXCL13, CXCL10, XCL1, and CXCL16, were …